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Originally published as Genetics Published Articles Ahead of Print on September 30, 2004.

Genetics, Vol. 169, 275-283, January 2005, Copyright © 2005
doi:10.1534/genetics.104.031559

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Mapping of a Milk Production Quantitative Trait Locus to a 420-kb Region on Bovine Chromosome 6

Hanne Gro Olsen*, Sigbjørn Lien*,{dagger},1, Mathieu Gautier*,{ddagger}, Heidi Nilsen*, Arne Roseth{dagger}, Paul R. Berg{dagger}, Kristil K. Sundsaasen{dagger}, Morten Svendsen§ and Theo H. E. Meuwissen*,{dagger}

* Department of Animal and Aquacultural Sciences, Agricultural University of Norway, N-1432 Aas, Norway
{dagger} Centre for Integrative Genetics, Agricultural University of Norway, N-1432 Aas, Norway
{ddagger} Laboratoire de Génétique Biochimique et de Cytogénétique, Institut National de Recherche Agronomique, 78352 Jouy en Josas, France
§ Geno Breeding and A.I. Organisation, N-1432 Aas, Norway

1 Corresponding author: Department of Animal and Aquacultural Sciences, Agricultural University of Norway, Box 5025, N-1432 Aas, Norway.
E-mail: sigbjorn.lien{at}iha.nlh.no

A QTL affecting milk production traits was previously mapped to an interval of 7.5 cM on chromosome 6 in Norwegian dairy cattle. This article aimed to refine this position by increasing the map density in the region by a set of single-nucleotide polymorphisms and analyzing the data with a combined linkage and linkage disequilibrium approach. Through a series of single- and multitrait and single- and multipoint analyses, the QTL was positioned to an interval surrounded by the genes ABCG2 and LAP3. As no recombinations were detected in this interval, physical mapping was required for further refining. By using radiation hybrid mapping as well as BAC clones, the bovine and human comparative maps in the region are resolved, and the QTL is mapped within a distance of 420 kb.




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