- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.104.030403v1
169/1/231 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Khazaeli, A. A.
- Articles by Curtsinger, J. W.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Khazaeli, A. A.
- Articles by Curtsinger, J. W.
Originally published as Genetics Published Articles Ahead of Print on September 30, 2004.
Genetics, Vol. 169, 231-242, January 2005, Copyright © 2005
doi:10.1534/genetics.104.030403
Longevity and Metabolism in Drosophila melanogaster
Genetic Correlations Between Life Span and Age-Specific Metabolic Rate in Populations Artificially Selected for Long Life
Aziz A. Khazaeli*,
Wayne Van Voorhies
and
James W. Curtsinger*,1
* Department of Ecology, Evolution and Behavior, University of Minnesota, Saint Paul, Minnesota 55108
Program in Molecular Biology, New Mexico State University, Las Cruces, New Mexico 88003-8003
1 Corresponding author: Department of Ecology, Evolution and Behavior, University of Minnesota, 1987 Upper Buford Circle, St. Paul, MN 55108.
E-mail: jwcurt{at}umn.edu
We measured age-specific metabolic rates in 2861 individual Drosophila melanogaster adult males to determine how genetic variation in metabolism is related to life span. Using recombinant inbred (RI) lines derived from populations artificially selected for long life, resting metabolic rates were measured at 5, 16, 29, and 47 days posteclosion, while life spans were measured in the same genotypes in mixed-sex population cages and in single-sex vials. We observed much heritable variation between lines in age-specific metabolic rates, evidence for genotype x age interaction, and moderate to large heritabilities at all ages except the youngest. Four traits exhibit evidence of coordinate genetic control: day 16 and day 29 metabolic rates, life span in population cages, and life span in vials. Quantitative trait loci (QTL) for those traits map to the same locations on three major chromosomes, and additive genetic effects are all positively correlated. In contrast, metabolic rates at the youngest and oldest ages are unrelated to metabolic rates at other ages and to survival. We suggest that artificial selection for long life via delayed reproduction also selects for increased metabolism at intermediate ages. Contrary to predictions of the "rate of living" theory, we find no evidence that metabolic rate varies inversely with survival, at the level of either line means or additive effects of QTL.
This article has been cited by other articles:
 |
|
 |
|
  J. Leips, P. Gilligan, and T. F. C. Mackay Quantitative Trait Loci With Age-Specific Effects on Fecundity in Drosophila melanogaster Genetics, March 1, 2006; 172(3): 1595 - 1605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Begun and H. A. Lindfors Rapid Evolution of Genomic Acp Complement in the melanogaster Subgroup of Drosophila Mol. Biol. Evol., October 1, 2005; 22(10): 2010 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Nuzhdin, A. A. Khazaeli, and J. W. Curtsinger Survival Analysis of Life Span Quantitative Trait Loci in Drosophila melanogaster Genetics, June 1, 2005; 170(2): 719 - 731. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Papers of Note Sci. Aging Knowl. Environ., February 2, 2005; 2005(5): nw5 - nw5. [Full Text]
|
|