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Genetics, Vol. 168, 1817-1825, December 2004, Copyright © 2004
doi:10.1534/genetics.104.033761
Spontaneous Mutations in Diploid Saccharomyces cerevisiae
More Beneficial Than Expected
Sarah B. Joseph1 and David W. Hall1,2
Section of Integrative Biology, University of Texas, Austin, Texas 78712
2 Corresponding author: Section of Integrative Biology, 1 University Station C-0930, University of Texas, Austin TX 78712.
E-mail: davehall{at}uts.cc.utexas.edu
We performed a 1012-generation mutation-accumulation (MA) experiment in the yeast, Saccharomyces cerevisiae. The MA lines exhibited a significant reduction in mean fitness and a significant increase in variance in fitness. We found that 5.75% of the fitness-altering mutations accumulated were beneficial. This finding contradicts the widely held belief that nearly all fitness-altering mutations are deleterious. The mutation rate was estimated as 6.3 x 10–5 mutations per haploid genome per generation and the average heterozygous fitness effect of a mutation as 0.061. These estimates are compatible with previous estimates in yeast.
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