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Genetics, Vol. 168, 1763-1771, November 2004, Copyright © 2004
doi:10.1534/genetics.104.029033
Uncovering Novel Cell Cycle Players Through the Inactivation of Securin in Budding Yeast
Sumeet Sarin*,
Karen E. Ross*,
Lorrie Boucher
,
Yvette Green*,
Mike Tyers and
Orna Cohen-Fix*,1
* The Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0840
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5G 1X5, Canada
1 Corresponding author: LMCB/NIDDK/NIH, 8 Center Dr., Bldg. 8, Room 319, Bethesda, MD 20892-0840.
E-mail: ornacf{at}helix.nih.gov
Budding yeast securin/Pds1p, an inhibitor of the anaphase activator separase/Esp1p, is involved in several checkpoint pathways and in promoting Esp1p's nuclear localization. Using a modified synthetic genetic array (SGA) screen for genes that become essential in the absence of Pds1p, we uncovered roles for uncharacterized genes in cell cycle processes, including Esp1p activation.
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