- THIS ARTICLE
- Full Text
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Kumar, J. P.
- Articles by Duffy, J. B.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Kumar, J. P.
- Articles by Duffy, J. B.
Genetics, Vol. 168, 877-893, October 2004, Copyright © 2004
doi:10.1534/genetics.104.029850
CREB Binding Protein Functions During Successive Stages of Eye Development in Drosophila
Justin P. Kumar1, Tazeen Jamal, Alex Doetsch, F. Rudolf Turner and Joseph B. Duffy
Department of Biology, Indiana University, Bloomington, Indiana 47401
1 Corresponding author: Department of Biology, Indiana University, 1001 E. Third St., Bloomington, IN 47401.
E-mail: jkumar{at}bio.indiana.edu
During the development of the compound eye of Drosophila several signaling pathways exert both positive and inhibitory influences upon an array of nuclear transcription factors to produce a near-perfect lattice of unit eyes or ommatidia. Individual cells within the eye are exposed to many extracellular signals, express multiple surface receptors, and make use of a large complement of cell-subtype-specific DNA-binding transcription factors. Despite this enormous complexity, each cell will make the correct developmental choice and adopt the appropriate cell fate. How this process is managed remains a poorly understood paradigm. Members of the CREB binding protein (CBP)/p300 family have been shown to influence development by (1) acting as bridging molecules between the basal transcriptional machinery and specific DNA-binding transcription factors, (2) physically interacting with terminal members of signaling cascades, (3) acting as transcriptional coactivators of downstream target genes, and (4) playing a key role in chromatin remodeling. In a screen for new genes involved in eye development we have identified the Drosophila homolog of CBP as a key player in both eye specification and cell fate determination. We have used a variety of approaches to define the role of CBP in eye development on a cell-by-cell basis.
This article has been cited by other articles:
 |
|
 |
|
  M. Stofanko, S. Y. Kwon, and P. Badenhorst A Misexpression Screen to Identify Regulators of Drosophila Larval Hemocyte Development Genetics, September 1, 2008; 180(1): 253 - 267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Lim, J. Lee, C. Choi, J. Kim, E. Doh, and J. Choe Functional Role of CREB-Binding Protein in the Circadian Clock System of Drosophila melanogaster Mol. Cell. Biol., July 1, 2007; 27(13): 4876 - 4890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Anderson, R. Bhandari, and J. P. Kumar A Genetic Screen Identifies Putative Targets and Binding Partners of CREB-Binding Protein in the Developing Drosophila Eye Genetics, December 1, 2005; 171(4): 1655 - 1672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Muller, S. J. Kugler, A. Preiss, D. Maier, and A. C. Nagel Genetic Modifier Screens on Hairless Gain-of-Function Phenotypes Reveal Genes Involved in Cell Differentiation, Cell Growth and Apoptosis in Drosophila melanogaster Genetics, November 1, 2005; 171(3): 1137 - 1152. [Abstract] [Full Text] [PDF]
|
|