- THIS ARTICLE
- Full Text
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Servin, B.
- Articles by Hospital, F.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Servin, B.
- Articles by Hospital, F.
Genetics, Vol. 168, 513-523, September 2004, Copyright © 2004
doi:10.1534/genetics.103.023358
Toward a Theory of Marker-Assisted Gene Pyramiding
Bertrand Servin*,
Olivier C. Martin
,
Marc Mézard and
Frédéric Hospital*,1
* UMR de Génétique Végétale INRA/CNRS/UPSud/INAP-G, Ferme du Moulon, 91190 Gif-sur-Yvette, France
Laboratoire de Physique Théorique et Modèles Statistiques, Bâtiment 100, Université Paris-Sud, 91405 Orsay Cedex, France
1 Corresponding author: Station de Génétique Végétale, INRA/UPS/INA-PG, Ferme du Moulon, 91190 Gif-sur-Yvette, France.
E-mail: fred{at}moulon.inra.fr
We investigate the best way to combine into a single genotype a series of target genes identified in different parents (gene pyramiding). Assuming that individuals can be selected and mated according to their genotype, the best method corresponds to an optimal succession of crosses over several generations (pedigree). For each pedigree, we compute the probability of success from the known recombination fractions between the target loci, as well as the number of individuals (population sizes) that should be genotyped over successive generations until the desired genotype is obtained. We provide an algorithm that generates and compares pedigrees on the basis of the population sizes they require and on their total duration (in number of generations) and finds the best gene-pyramiding scheme. Examples are given for eight target genes and are compared to a reference genotype selection method with random mating. The best gene-pyramiding method combines the eight targets in three generations less than the reference method while requiring fewer genotypings.
This article has been cited by other articles:
 |
|
 |
|
  E. M. Septiningsih, A. M. Pamplona, D. L. Sanchez, C. N. Neeraja, G. V. Vergara, S. Heuer, A. M. Ismail, and D. J. Mackill Development of submergence-tolerant rice cultivars: the Sub1 locus and beyond Ann. Bot., January 1, 2009; 103(2): 151 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ishii, T. Hayashi, and K. Yonezawa Optimization of the Marker-based Procedures for Pyramiding Genes from Multiple Donor Lines: III. Multiple-Gene Assemblage Using Background Marker Selection Crop Sci., November 24, 2008; 48(6): 2123 - 2131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. C. Collins, F. Tardieu, and R. Tuberosa Quantitative Trait Loci and Crop Performance under Abiotic Stress: Where Do We Stand? Plant Physiology, June 1, 2008; 147(2): 469 - 486. [Full Text] [PDF]
|
|
|
|
|
|
Y. Xu and J. H. Crouch Marker-Assisted Selection in Plant Breeding: From Publications to Practice Crop Sci., March 19, 2008; 48(2): 391 - 407. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C.Y Collard and D. J Mackill Marker-assisted selection: an approach for precision plant breeding in the twenty-first century Phil Trans R Soc B, February 12, 2008; 363(1491): 557 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Mumm Backcross versus Forward Breeding in the Development of Transgenic Maize Hybrids: Theory and Practice Crop Sci., December 18, 2007; 47(Supplement_3): S-164 - S-171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ishii and K. Yonezawa Optimization of the Marker-Based Procedures for Pyramiding Genes from Multiple Donor Lines: II. Strategies for Selecting the Objective Homozygous Plant Crop Sci., September 1, 2007; 47(5): 1878 - 1886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zhong and J.-L. Jannink Using Quantitative Trait Loci Results to Discriminate Among Crosses on the Basis of Their Progeny Mean and Variance Genetics, September 1, 2007; 177(1): 567 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, S. C. Chapman, D. G. Bonnett, G. J. Rebetzke, and J. Crouch Application of Population Genetic Theory and Simulation Models to Efficiently Pyramid Multiple Genes via Marker-Assisted Selection Crop Sci., March 1, 2007; 47(2): 582 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Udall and J. F. Wendel Polyploidy and Crop Improvement Crop Sci., November 1, 2006; 46(Supplement_1): S-3 - S-14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Hospital Selection in backcross programmes Phil Trans R Soc B, July 29, 2005; 360(1459): 1503 - 1511. [Abstract] [Full Text] [PDF]
|
|