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Genetics, Vol. 168, 49-63, September 2004, Copyright © 2004
doi:10.1534/genetics.104.027961
Gene Conversion and Crossing Over Along the 405-kb Left Arm of Saccharomyces cerevisiae Chromosome VII
Anna Malkova*,1,2,
Johanna Swanson
,1,3,
Miriam German*,1,4,
John H. McCusker*,5,
Elizabeth A. Housworth
,
Franklin W. Stahl and
James E. Haber*,6
* Department of Biology and Rosenstiel Center, Brandeis University, Waltham, Massachusetts 02454-9110
Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229
Department of Mathematics and Department of Biology, Indiana University, Bloomington, Indiana 47405
6 Corresponding author: Department of Biology and Rosenstiel Center, Brandeis University, 415 South St., Mailstop 029, Waltham, MA 02454-9110.
E-mail: haber{at}brandeis.edu
Gene conversions and crossing over were analyzed along 10 intervals in a 405-kb region comprising nearly all of the left arm of chromosome VII in Saccharomyces cerevisiae. Crossover interference was detected in all intervals as measured by a reduced number of nonparental ditypes. We have evaluated interference between crossovers in adjacent intervals by methods that retain the information contained in tetrads as opposed to single segregants. Interference was seen between intervals when the distance in the region adjacent to a crossover was <
35 cM (90 kb). At the met13 locus, which exhibits 9% gene conversions, those gene conversions accompanied by crossing over exerted interference in exchanges in an adjacent interval, whereas met13 gene conversions without an accompanying exchange did not show interference. The pattern of exchanges along this chromosome arm can be represented by a counting model in which there are three nonexchange events between adjacent exchanges; however, maximum-likelihood analysis suggests that 8–12% of the crossovers on chromosome VII arise by a separate, noninterfering mechanism.
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