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Genetics, Vol. 167, 2133-2137, August 2004, Copyright © 2004
doi:10.1534/genetics.103.024844

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A Fast Algorithm for Functional Mapping of Complex Traits

Wei Zhao, Rongling Wu1, Chang-Xing Ma and George Casella

Department of Statistics, University of Florida, Gainesville, Florida 32611

1 Corresponding author: Department of Statistics, 533 McCarty Hall C, University of Florida, Gainesville, FL 32611.
E-mail: rwu{at}stat.ufl.edu

By integrating the underlying developmental mechanisms for the phenotypic formation of traits into a mapping framework, functional mapping has emerged as an important statistical approach for mapping complex traits. In this note, we explore the feasibility of using the simplex algorithm as an alternative to solve the mixture-based likelihood for functional mapping of complex traits. The results from the simplex algorithm are consistent with those from the traditional EM algorithm, but the simplex algorithm has considerably reduced computational times. Moreover, because of its nonderivative nature and easy implementation with current software, the simplex algorithm enjoys an advantage over the EM algorithm in the dynamic modeling and analysis of complex traits.




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