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Genetics, Vol. 167, 1525-1528, July 2004, Copyright © 2004
doi:10.1534/genetics.104.029819
Does Random X-Inactivation in Mammals Reflect a Random Choice Between Two X Chromosomes?
Benjamin R. Williams* and
Chao-ting Wu*,
,1
* Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
Station for Natural Studies, Brookline, Massachusetts 02446
1 Corresponding author: Department of Genetics, Harvard Medical School, 77 Ave. Louis Pasteur, Boston, MA 02115.
E-mail: twu{at}genetics.med.harvard.edu
Inactivation of the maternal or paternal X chromosome in a mammalian embryonic XX cell is believed to involve random choice between the two X's. We propose two alternative models. One suggests that choice is not random, while the other is consistent with random choice, but not one between two X's.
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