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-Protein Negatively Regulates Asexual Sporulation and Plays a Positive Role in Conidial Germination in Aspergillus nidulans
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* Division of Biological Sciences, Chonbuk National University, Chonju 561-756, Republic of Korea
Institute for Basic Sciences, Chonbuk National University, Chonju 561-756, Republic of Korea
Institute for Molecular Biology and Genetic Engineering, Chonbuk National University, Chonju 561-756, Republic of Korea
Division of Life Sciences, Wonkwang University, Iksan 570-749, Republic of Korea
1 Corresponding author: Division of Biological Sciences, Chonbuk National University, Duckjin-dong 1ga, Chonju 561-756, Republic of Korea.
E-mail: goodear{at}moak.chonbuk.ac.kr
-protein homolog from Aspergillus nidulans. To investigate the cellular function of GanB, various mutant strains were isolated. Deletion of constitutively inactive ganB mutants showed conidiation and derepressed brlA expression in a submerged culture. Constitutive activation of GanB caused a reduction in hyphal growth and a severe defect in asexual sporulation. We therefore propose that GanB may negatively regulate asexual sporulation through the BrlA pathway. In addition, deletion or constitutive inactivation of GanB reduced germination rate while constitutive activation led to precocious germination. Furthermore, conidia of a constitutively active mutant could germinate even without carbon source. Taken together, these results indicated that GanB plays a positive role during germination, possibly through carbon source sensing, and negatively regulates asexual conidiation in A. nidulans. This article has been cited by other articles:
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