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Genetics, Vol. 167, 1133-1142, July 2004, Copyright © 2004
doi:10.1534/genetics.104.026260
A Role for DNA Polymerase 
in Gene Conversion and Crossing Over During Meiosis in Saccharomyces cerevisiae
Laurent Maloisel*,1,
Jaya Bhargava
,2 and
G. Shirleen Roeder*,,
,3
* Howard Hughes Medical Institute, Cellular and Developmental Biology
Department of Molecular, Cellular and Developmental Biology
Department of Genetics, Yale University, New Haven, Connecticut 06520-8103
3 Corresponding author: Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, CT 06520-8103.
E-mail: shirleen.roeder{at}yale.edu
A screen for mutants of budding yeast defective in meiotic gene conversion identified a novel allele of the POL3 gene. POL3 encodes the catalytic subunit of DNA polymerase 
, an essential DNA polymerase involved in genomic DNA replication. The new allele, pol3-ct, specifies a protein missing the last four amino acids. pol3-ct shows little or no defect in DNA replication, but displays a reduction in the length of meiotic gene conversion tracts and a decrease in crossing over. We propose a model in which DNA synthesis determines the length of strand exchange intermediates and influences their resolution toward crossing over.
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