Genetics, Vol. 167, 761-781, June 2004, Copyright © 2004
doi:10.1534/genetics.104.026427

The BDGP Gene Disruption Project

Single Transposon Insertions Associated With 40% of Drosophila Genes

Hugo J. Bellen^*, Robert W. Levis, Guochun Liao^,1, Yuchun He^*, Joseph W. Carlson, Garson Tsang, Martha Evans-Holm, P. Robin Hiesinger^*, Karen L. Schulze^*, Gerald M. Rubin, Roger A. Hoskins and Allan C. Spradling^,2

^* Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030
Department of Embryology, Howard Hughes Medical Institute Research Laboratories, Carnegie Institution of Washington, Baltimore, Maryland 21210
Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, University of California, Berkeley, California 94720-3200
Lawrence Berkeley National Laboratory, Berkeley, California 94720-3200

² Corresponding author: Department of Embryology, Howard Hughes Medical Institute, Carnegie Institution of Washington, 115 W. University Pkwy., Baltimore, MD 21210.
E-mail: spradling{at}ciwemb.edu

The Berkeley Drosophila Genome Project (BDGP) strives to disrupt each Drosophila gene by the insertion of a single transposable element. As part of this effort, transposons in >30,000 fly strains were localized and analyzed relative to predicted Drosophila gene structures. Approximately 6300 lines that maximize genomic coverage were selected to be sent to the Bloomington Stock Center for public distribution, bringing the size of the BDGP gene disruption collection to 7140 lines. It now includes individual lines predicted to disrupt 5362 of the 13,666 currently annotated Drosophila genes (39%). Other lines contain an insertion at least 2 kb from others in the collection and likely mutate additional incompletely annotated or uncharacterized genes and chromosomal regulatory elements. The remaining strains contain insertions likely to disrupt alternative gene promoters or to allow gene misexpression. The expanded BDGP gene disruption collection provides a public resource that will facilitate the application of Drosophila genetics to diverse biological problems. Finally, the project reveals new insight into how transposons interact with a eukaryotic genome and helps define optimal strategies for using insertional mutagenesis as a genomic tool.

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				K. Chen, C. Merino, S. J. Sigrist, and D. E. Featherstone The 4.1 Protein Coracle Mediates Subunit-Selective Anchoring of Drosophila Glutamate Receptors to the Postsynaptic Actin Cytoskeleton J. Neurosci., July 13, 2005; 25(28): 6667 - 6675. [Abstract] [Full Text] [PDF]

				F. Yu, H. Wang, H. Qian, R. Kaushik, M. Bownes, X. Yang, and W. Chia Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions Genes & Dev., June 1, 2005; 19(11): 1341 - 1353. [Abstract] [Full Text] [PDF]

				E. C. Lai, F. Roegiers, X. Qin, Y. N. Jan, and G. M. Rubin The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta Development, May 15, 2005; 132(10): 2319 - 2332. [Abstract] [Full Text] [PDF]

				T. F. C. Mackay, S. L. Heinsohn, R. F. Lyman, A. J. Moehring, T. J. Morgan, and S. M. Rollmann Genetics and genomics of Drosophila mating behavior PNAS, May 3, 2005; 102(suppl_1): 6622 - 6629. [Abstract] [Full Text] [PDF]

				S. Winkler, A. Schwabedissen, D. Backasch, C. Bokel, C. Seidel, S. Bonisch, M. Furthauer, A. Kuhrs, L. Cobreros, M. Brand, et al. Target-selected mutant screen by TILLING in Drosophila Genome Res., May 1, 2005; 15(5): 718 - 723. [Abstract] [Full Text] [PDF]

				B. T. Sage, J. L. Jones, A. L. Holmes, M. D. Wu, and A. K. Csink Sequence Elements in cis Influence Heterochromatic Silencing in trans Mol. Cell. Biol., January 1, 2005; 25(1): 377 - 388. [Abstract] [Full Text] [PDF]

				D. Devenport and N. H. Brown Morphogenesis in the absence of integrins: mutation of both Drosophila {beta} subunits prevents midgut migration Development, November 1, 2004; 131(21): 5405 - 5415. [Abstract] [Full Text] [PDF]

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