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Genetic Interactions With C-Terminal Domain (CTD) Kinases and the CTD of RNA Pol II Suggest a Role for ESS1 in Transcription Initiation and Elongation in Saccharomyces cerevisiae
Cathy B. Wilcoxa, Anne Rossettinia, and Steven D. Hanesa,ba Molecular Genetics Program, Wadsworth Center, New York State Department of Health, Albany, New York 12208
b Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, New York 12208
Corresponding author: Steven D. Hanes, 120 New Scotland Ave., Albany, NY 12208., hanes{at}wadsworth.org (E-mail)
Communicating editor: F. WINSTON
mutants. The interactions suggest that Ess1 opposes the functions of these kinases, which are thought to function in preinitiation and elongation. Using a series of CTD substitution alleles, we also identified Ser5-Pro6 as a potential target for Ess1 isomerization within the first "half" of the CTD repeats. On the basis of the results, we suggest a model in which Ess1-directed conformational changes promote dephosphorylation of Ser5 to stimulate preinitiation complex formation and, later, to inhibit elongation.
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