Saccharomyces cerevisiae SSD1-V Confers Longevity by a Sir2p-Independent Mechanism

Corresponding author: Matt Kaeberlein, Health Sciences Bldg., K-222, Seattle, Washington 98195-7730., kaeber{at}u.washington.edu (E-mail)

Communicating editor: B. J. ANDREWS

The SSD1 gene of Saccharomyces cerevisiae is a polymorphic locus that affects diverse cellular processes including cell integrity, cell cycle progression, and growth at high temperature. We show here that the SSD1-V allele is necessary for cells to achieve extremely long life span. Furthermore, addition of SSD1-V to cells can increase longevity independently of SIR2, although SIR2 is necessary for SSD1-V cells to attain maximal life span. Past studies of yeast aging have been performed in short-lived ssd1-d strain backgrounds. We propose that SSD1-V defines a previously undescribed pathway affecting cellular longevity and suggest that future studies on longevity-promoting genes should be carried out in long-lived SSD1-V strains.

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