A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila

Corresponding author: Atanu Duttaroy, Howard University, 415 College St., NW, Washington, DC 20059., aduttaroy{at}howard.edu (E-mail)

Communicating editor: J. BIRCHLER

A null mutation for the Sod2 gene, Sod2ⁿ²⁸³, was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodⁿ²⁸³/Sodⁿ²⁸³) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2^-/- progeny suffer neonatal lethality. Sod^n283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.

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