help button home button Genetics J Neurosci
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Infante, J. J.
Right arrow Articles by Young, E. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Infante, J. J.
Right arrow Articles by Young, E. T.
Genetics, Vol. 165, 1745-1759, December 2003, Copyright © 2003

Genome-Wide Amplifications Caused by Chromosomal Rearrangements Play a Major Role in the Adaptive Evolution of Natural Yeast

Juan J. Infantea, Kenneth M. Dombekb, Laureana Rebordinosa, Jesús M. Cantorala, and Elton T. Youngb
a Laboratorio de Microbiología y Genética, CASEM, Universidad de Cádiz, 11510 Puerto Real, Cádiz, Spain
b Department of Biochemistry, University of Washington, Seattle, Washington 98195-7350

Corresponding author: Elton T. Young, Box 357350, 1959 NE Pacific Ave., University of Washington, Seattle, WA 98195-7350., ety{at}u.washington.edu (E-mail)

Communicating editor: L. S. SYMINGTON

The relative importance of gross chromosomal rearrangements to adaptive evolution has not been precisely defined. The Saccharomyces cerevisiae flor yeast strains offer significant advantages for the study of molecular evolution since they have recently evolved to a high degree of specialization in a very restrictive environment. Using DNA microarray technology, we have compared the genomes of two prominent variants of S. cerevisiae flor yeast strains. The strains differ from one another in the DNA copy number of 116 genomic regions that comprise 38% of the genome. In most cases, these regions are amplicons flanked by repeated sequences or other recombination hotspots previously described as regions where double-strand breaks occur. The presence of genes that confer specific characteristics to the flor yeast within the amplicons supports the role of chromosomal rearrangements as a major mechanism of adaptive evolution in S. cerevisiae. We propose that nonallelic interactions are enhanced by ethanol- and acetaldehyde-induced double-strand breaks in the chromosomal DNA, which are repaired by pathways that yield gross chromosomal rearrangements. This mechanism of chromosomal evolution could also account for the sexual isolation shown among the flor yeast.




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
J. E. Mendell, K. D. Clements, J. H. Choat, and E. R. Angert
From the Cover: Extreme polyploidy in a large bacterium
PNAS, May 6, 2008; 105(18): 6730 - 6734.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. M. Kim, J. O. Korbel, and M. B. Gerstein
Positive selection at the protein network periphery: Evaluation in terms of structural constraints and cellular context
PNAS, December 18, 2007; 104(51): 20274 - 20279.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
U. Bergthorsson, D. I. Andersson, and J. R. Roth
Ohno's dilemma: Evolution of new genes under continuous selection
PNAS, October 23, 2007; 104(43): 17004 - 17009.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
G. Lunter
Probabilistic whole-genome alignments reveal high indel rates in the human and mouse genomes
Bioinformatics, July 1, 2007; 23(13): i289 - i296.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
A. Crombach and P. Hogeweg
Chromosome Rearrangements and the Evolution of Genome Structuring and Adaptability
Mol. Biol. Evol., May 1, 2007; 24(5): 1130 - 1139.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Fidalgo, R. R. Barrales, J. I. Ibeas, and J. Jimenez
Adaptive evolution by mutations in the FLO11 gene
PNAS, July 25, 2006; 103(30): 11228 - 11233.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
S. Goel, Z. Chen, Y. Akiyama, J. A. Conner, M. Basu, G. Gualtieri, W. W. Hanna, and P. Ozias-Akins
Comparative Physical Mapping of the Apospory-Specific Genomic Region in Two Apomictic Grasses: Pennisetum squamulatum and Cenchrus ciliaris
Genetics, May 1, 2006; 173(1): 389 - 400.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
R. Koszul, B. Dujon, and G. Fischer
Stability of Large Segmental Duplications in the Yeast Genome
Genetics, April 1, 2006; 172(4): 2211 - 2222.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
J. A. Fraser, J. C. Huang, R. Pukkila-Worley, J. A. Alspaugh, T. G. Mitchell, and J. Heitman
Chromosomal Translocation and Segmental Duplication in Cryptococcus neoformans
Eukaryot. Cell, February 1, 2005; 4(2): 401 - 406.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
A. M. Snijders, N. J. Nowak, B. Huey, J. Fridlyand, S. Law, J. Conroy, T. Tokuyasu, K. Demir, R. Chiu, J.-H. Mao, et al.
Mapping segmental and sequence variations among laboratory mice using BAC array CGH
Genome Res., February 1, 2005; 15(2): 302 - 311.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. M. Avery, S. A. Willetts, and S. V. Avery
Genetic Dissection of the Phospholipid Hydroperoxidase Activity of Yeast Gpx3 Reveals Its Functional Importance
J. Biol. Chem., November 5, 2004; 279(45): 46652 - 46658.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the Genetics Society of America.