Compositional Biases and Polyalanine Runs in Humans

Compositional Biases and Polyalanine Runs in Humans

Julie Cocquet^a, Elfride De Baere^b, Sandrine Caburet^a, and Reiner A. Veitia^a
^a INSERM E0021 and U361, Reproduction et Physiopathologie Obstétricale, Hôpital Cochin, 75014 Paris, France
^b Department of Medical Genetics, Ghent University Hospital, B-9000 Ghent, Belgium

Corresponding author: Reiner A. Veitia, Reproduction et Physiopathologie Obstétricale, Hôpital Cochin, Pavillon Baudelocque, 123 Bd. de Port Royal, 75014 Paris, France., veitia{at}cochin.inserm.fr (E-mail)

Communicating editor: M. NOOR

Human proteins containing polyalanine tracts tend to have runsof other amino acids and their open reading frames (ORFs) displaya biased codon usage. Their alanine, glycine, proline, and histidinecontent strongly correlates with the GC content of the thirdcodon base, suggesting that the compositional specificity ofthese proteins is dictated to a great extent by the evolutionof their ORFs.

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