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Genetics, Vol. 165, 1599-1605, November 2003, Copyright © 2003

Rank-Based Statistical Methodologies for Quantitative Trait Locus Mapping

Fei Zoua, Brian S. Yandellb, and Jason P. Fineb
a Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599
b Department of Statistics, University of Wisconsin, Madison, Wisconsin 53706

Corresponding author: Fei Zou, University of North Carolina, 3107D McGavran-Greenberg Hall, CB 7420, Chapel Hill, NC 27599., fzou{at}bios.unc.edu (E-mail)

Communicating editor: Z-B. ZENG

This article addresses the identification of genetic loci (QTL and elsewhere) that influence nonnormal quantitative traits with focus on experimental crosses. QTL mapping is typically based on the assumption that the traits follow normal distributions, which may not be true in practice. Model-free tests have been proposed. However, nonparametric estimation of genetic effects has not been studied. We propose an estimation procedure based on the linear rank test statistics. The properties of the new procedure are compared with those of traditional likelihood-based interval mapping and regression interval mapping via simulations and a real data example. The results indicate that the nonparametric method is a competitive alternative to the existing parametric methodologies.




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