Genetics, Vol. 165, 929-934, October 2003, Copyright © 2003

A Function for Subtelomeric DNA in Saccharomyces cerevisiae

Arnold B. Bartona, Yuping Sua, Jacque Lamba, Dianna Barbera, and David B. Kabacka
a Department of Microbiology and Molecular Genetics, International Center for Public Health, UMDNJ-New Jersey Medical School, Graduate School of Biomedical Sciences, Newark, New Jersey 07103

Corresponding author: David B. Kaback, International Center for Public Health, UMDNJ-New Jersey Medical School, P.O. Box 1709, Newark, NJ 07101-1709., kaback{at}umdnj.edu (E-mail)

Communicating editor: M. JOHNSTON

The subtelomeric DNA sequences from chromosome I of Saccharomyces cerevisiae are shown to be inherently poor substrates for meiotic recombination. On the basis of these results and prior observations that crossovers near telomeres do not promote efficient meiosis I segregation, we suggest that subtelomeric sequences evolved to prevent recombination from occurring where it cannot promote efficient segregation.




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