Haplotype Sharing Refines the Location of an Imprinted Quantitative Trait Locus With Major Effect on Muscle Mass to a 250-kb Chromosome Segment Containing the Porcine IGF2 Gene

Haplotype Sharing Refines the Location of an Imprinted Quantitative Trait Locus With Major Effect on Muscle Mass to a 250-kb Chromosome Segment Containing the Porcine IGF2 Gene

Carine Nezer^a, Catherine Collette^a, Laurence Moreau^a, Benoît Brouwers^a, Jong-Joo Kim^a, Elisabetta Giuffra^c, Nadine Buys^d, Leif Andersson^b, and Michel Georges^a
^a Department of Genetics, Faculty of Veterinary Medicine, University of Liège, 4000-Liège, Belgium,
^b Department of Medical Biochemistry and Microbiology, Uppsala University, S-751 24 Uppsala, Sweden,
^c Centro Ricerche Studi Agroalimentari FPTP-CERSA, LITA, 20090 Segrate, Italy
^d Gentec, 9255 Buggenhout, Belgium

Corresponding author: Michel Georges, Faculty of Veterinary Medicine, University of Liège (B43), 20 Bd de Colonster, 4000-Liège, Belgium., michel.georges{at}ulg.ac.be (E-mail)

Communicating editor: C. HALEY

We herein describe the fine mapping of an imprinted QTL withmajor effect on muscle mass that was previously assigned todistal SSC2p in the pig. The proposed approach exploits linkagedisequilibrium in combination with QTL genotyping by marker-assistedsegregation analysis. By identifying a haplotype shared by all"Q" chromosomes, we map the QTL to an $~$ 250-kb chromosome segmentcontaining INS and IGF2 as the only known paternally expressedgenes. This considerably reinforces the candidacy of these genes,justifying their detailed analysis.

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