Genetics, Vol. 164, 829-833, June 2003, Copyright © 2003

False Discovery Rate in Linkage and Association Genome Screens for Complex Disorders

Chiara Sabattia, Susan Serviceb, and Nelson Freimerb
a Departments of Human Genetics and Statistics, University of California, Los Angeles, California 90095-7088
b Center for Neurobehavioral Genetics, Neuropsychiatric Institute, and Departments of Psychiatry and Human Genetics, University of California, Los Angeles, California 90095-1761

Corresponding author: Chiara Sabatti, UCLA School of Medicine, 695 Charles E. Young Dr. S., Los Angeles, CA 90095-7088., csabatti{at}mednet.ucla.edu (E-mail)

Communicating editor: G. CHURCHILL

We explore the implications of the false discovery rate (FDR) controlling procedure in disease gene mapping. With the aid of simulations, we show how, under models commonly used, the simple step-down procedure introduced by Benjamini and Hochberg controls the FDR for the dependent tests on which linkage and association genome screens are based. This adaptive multiple comparison procedure may offer an important tool for mapping susceptibility genes for complex diseases.




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