Evolutionary, Structural and Biochemical Evidence for a New Interaction Site of the Leptin Obesity Protein

Evolutionary, Structural and Biochemical Evidence for a New Interaction Site of the Leptin Obesity Protein

Eric A. Gaucher^a, Michael M. Miyamoto^b, and Steven A. Benner^a
^a NASA Astrobiology Institute and Foundation for Applied Molecular Evolution, University of Florida, Gainesville, Florida, 32611-7200
^b Department of Zoology, University of Florida, Gainesville, Florida, 32611-8525

Corresponding author: Eric A. Gaucher, Department of Chemistry, 440 Leigh Hall, University of Florida, Gainesville, FL 32611-7200., gaucher{at}ufl.edu (E-mail)

Communicating editor: Y.-X. FU

The Leptin protein is central to the regulation of energy metabolismin mammals. By integrating evolutionary, structural, and biochemicalinformation, a surface segment, outside of its known receptorcontacts, is predicted as a second interaction site that mayhelp to further define its roles in energy balance and its functionaldifferences between humans and other mammals.

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