The Coalescent and Infinite-Site Model of a Small Multigene Family

Corresponding author: Hideki Innan, School of Public Health, University of Texas Health Science Center, 1200 Hermann Pressler, Houston, TX 77030., hinnan{at}sph.uth.tmc.edu (E-mail)

Communicating editor: J. HEY

The infinite-site model of a small multigene family with two duplicated genes is studied. The expectations of the amounts of nucleotide variation within and between two genes and linkage disequilibrium are obtained, and a coalescent-based method for simulating patterns of polymorphism in a small multigene family is developed. The pattern of DNA variation is much more complicated than that in a single-copy gene, which can be simulated by the standard coalescent. Using the coalescent simulation of duplicated genes, the applicability of statistical tests of neutrality to multigene families is considered.

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