help button home button Genetics J Virology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Laporte, V.
Right arrow Articles by Charlesworth, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Laporte, V.
Right arrow Articles by Charlesworth, B.
Genetics, Vol. 162, 501-519, September 2002, Copyright © 2002

Effective Population Size and Population Subdivision in Demographically Structured Populations

Valérie Laportea and Brian Charleswortha
a Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom

Corresponding author: Valérie Laporte, Animal and Population Biology, University of Edinburgh, W. Mains Rd., Edinburgh EH9 3JT, UK., valerie.laporte{at}ed.ac.uk (E-mail)

Communicating editor: G. B. GOLDING

A fast-timescale approximation is applied to the coalescent process in a single population, which is demographically structured by sex and/or age. This provides a general expression for the probability that a pair of alleles sampled from the population coalesce in the previous time interval. The effective population size is defined as the reciprocal of twice the product of generation time and the coalescence probability. Biologically explicit formulas for effective population size with discrete generations and separate sexes are derived for a variety of different modes of inheritance. The method is also applied to a nuclear gene in a population of partially self-fertilizing hermaphrodites. The effects of population subdivision on a demographically structured population are analyzed, using a matrix of net rates of movement of genes between different local populations. This involves weighting the migration probabilities of individuals of a given age/sex class by the contribution of this class to the leading left eigenvector of the matrix describing the movements of genes between age/sex classes. The effects of sex-specific migration and nonrandom distributions of offspring number on levels of genetic variability and among-population differentiation are described for different modes of inheritance in an island model. Data on DNA sequence variability in human and plant populations are discussed in the light of the results.




This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
S. Nakagome, J. Pecon-Slattery, and R. Masuda
Unequal Rates of Y Chromosome Gene Divergence during Speciation of the Family Ursidae
Mol. Biol. Evol., July 1, 2008; 25(7): 1344 - 1356.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
G. Muir and D. Filatov
A Selective Sweep in the Chloroplast DNA of Dioecious Silene (Section Elisanthe)
Genetics, October 1, 2007; 177(2): 1239 - 1247.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
U. Arunyawat, W. Stephan, and T. Stadler
Using Multilocus Sequence Data to Assess Population Structure, Natural Selection, and Linkage Disequilibrium in Wild Tomatoes
Mol. Biol. Evol., October 1, 2007; 24(10): 2310 - 2322.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. A. Dyer, B. Charlesworth, and J. Jaenike
Chromosome-wide linkage disequilibrium as a consequence of meiotic drive
PNAS, January 30, 2007; 104(5): 1587 - 1592.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
L. J. Lawson Handley, L. Berset-Brandli, and N. Perrin
Disentangling Reasons for Low Y Chromosome Variation in the Greater White-Toothed Shrew (Crocidura russula)
Genetics, June 1, 2006; 173(2): 935 - 942.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
M. Lynch
The Origins of Eukaryotic Gene Structure
Mol. Biol. Evol., February 1, 2006; 23(2): 450 - 468.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. E. Ironside and D. A. Filatov
Extreme Population Structure and High Interspecific Divergence of the Silene Y Chromosome
Genetics, October 1, 2005; 171(2): 705 - 713.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
N. D. Singh, J. C. Davis, and D. A. Petrov
X-Linked Genes Evolve Higher Codon Bias in Drosophila and Caenorhabditis
Genetics, September 1, 2005; 171(1): 145 - 155.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Lu and C.-I Wu
Weak selection revealed by the whole-genome comparison of the X chromosome and autosomes of human and chimpanzee
PNAS, March 15, 2005; 102(11): 4063 - 4067.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
P. K. Ingvarsson
Nucleotide Polymorphism and Linkage Disequilibrium Within and Among Natural Populations of European Aspen (Populus tremula L., Salicaceae)
Genetics, February 1, 2005; 169(2): 945 - 953.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Hey and R. Nielsen
Multilocus Methods for Estimating Population Sizes, Migration Rates and Divergence Time, With Applications to the Divergence of Drosophila pseudoobscura and D. persimilis
Genetics, June 1, 2004; 167(2): 747 - 760.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
N. Yu, M. I. Jensen-Seaman, L. Chemnick, O. Ryder, and W.-H. Li
Nucleotide Diversity in Gorillas
Genetics, March 1, 2004; 166(3): 1375 - 1383.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
S. E. Ramos-Onsins, B. E. Stranger, T. Mitchell-Olds, and M. Aguade
Multilocus Analysis of Variation and Speciation in the Closely Related Species Arabidopsis halleri and A. lyrata
Genetics, January 1, 2004; 166(1): 373 - 388.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the Genetics Society of America.