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Genetics, Vol. 162, 135-153, September 2002, Copyright © 2002

Courtship and Other Behaviors Affected by a Heat-Sensitive, Molecularly Novel Mutation in the cacophony Calcium-Channel Gene of Drosophila

Betty Chana, Adriana Villellaa, Pablo Funesa, and Jeffrey C. Halla
a Department of Biology, Brandeis University, Waltham, Massachussetts 02454

Corresponding author: Jeffrey C. Hall, Brandeis University, 415 South St., Waltham, MA 02454-9110., hall{at}brandeis.edu (E-mail)

Communicating editor: M. NOOR

The cacophony (cac) locus of Drosophila melanogaster, which encodes a calcium-channel subunit, has been mutated to cause courtship-song defects or abnormal responses to visual stimuli. However, the most recently isolated cac mutant was identified as an enhancer of a comatose mutation's effects on general locomotion. We analyzed the cacTS2 mutation in terms of its intragenic molecular change and its effects on behaviors more complex than the fly's elementary ability to move. The molecular etiology of this mutation is a nucleotide substitution that causes a proline-to-serine change in a region of the polypeptide near its EF hand. Given that this motif is involved in channel inactivation, it was intriguing that cacTS2 males generate song pulses containing larger-than-normal numbers of cycles—provided that such males are exposed to an elevated temperature. Similar treatments caused only mild visual-response abnormalities and generic locomotor sluggishness. These results are discussed in the context of calcium-channel functions that subserve certain behaviors and of defects exhibited by the original cacophony mutant. Despite its different kind of amino-acid substitution, compared with that of cacTS2, cacS males sing abnormally in a manner that mimics the new mutant's heat-sensitive song anomaly.




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