Genetics, Vol. 161, 1651-1659, August 2002, Copyright © 2002

X Chromosome Effect on Maternal Recombination and Meiotic Drive in the Mouse

Elena de la Casa-Esperóna, J Concepción Loredo-Ostid, Fernando Pardo-Manuel de Villenac, Tammi L. Briscoea, Jan Michel Malettea, Joe E. Vaughana, Kenneth Morgand,e, and Carmen Sapienzaa,b
a Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140,
b Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140,
c Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7264
d Department of Human Genetics, McGill University, and the Research Institute of the McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada
e Department of Medicine, McGill University, and the Research Institute of the McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada

Corresponding author: Carmen Sapienza, Temple University School of Medicine, 3307 North Broad St., Philadelphia, PA 19140., sapienza{at}unix.temple.edu (E-mail)

Communicating editor: N. JENKINS

We observed that maternal meiotic drive favoring the inheritance of DDK alleles at the Om locus on mouse chromosome 11 was correlated with the X chromosome inactivation phenotype of (C57BL/6-Pgk1a x DDK)F1 mothers. The basis for this unexpected observation appears to lie in the well-documented effect of recombination on meiotic drive that results from nonrandom segregation of chromosomes. Our analysis of genome-wide levels of meiotic recombination in females that vary in their X-inactivation phenotype indicates that an allelic difference at an X-linked locus is responsible for modulating levels of recombination in oocytes.




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