rugose (rg), a Drosophila A kinase Anchor Protein, Is Required for Retinal Pattern Formation and Interacts Genetically With Multiple Signaling Pathways

rugose (rg), a Drosophila A kinase Anchor Protein, Is Required for Retinal Pattern Formation and Interacts Genetically With Multiple Signaling Pathways

Hoda K. Shamloula, Mkajuma P. Mbogho, Angel C. Pimentel^a, Zosia M. A. Chrzanowska-Lightowlers^b, Vanneta Hyatt^a, Hideyuki Okano^c, and Tadmiri R. Venkatesh^a
^a Department of Biology, City College and The Graduate Center, City University of New York, New York 10031,
^b University of New Castle upon Tyne, New Castle upon Tyne, NE2 4HH, United Kingdom
^c Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan

Corresponding author: Tadmiri R. Venkatesh, City College of New York, 138th St. and Convent Ave., New York, NY 10031., venky{at}sci.ccny.cuny.edu (E-mail)

Communicating editor: T. C. KAUFMAN

In the developing Drosophila eye, cell fate determination andpattern formation are directed by cell-cell interactions mediatedby signal transduction cascades. Mutations at the rugose locus(rg) result in a rough eye phenotype due to a disorganized retinaand aberrant cone cell differentiation, which leads to reductionor complete loss of cone cells. The cone cell phenotype is sensitiveto the level of rugose gene function. Molecular analyses showthat rugose encodes a Drosophila A kinase anchor protein (DAKAP550). Genetic interaction studies show that rugose interactswith the components of the EGFR- and Notch-mediated signalingpathways. Our results suggest that rg is required for correctretinal pattern formation and may function in cell fate determinationthrough its interactions with the EGFR and Notch signaling pathways.

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