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Spt3 Plays Opposite Roles in Filamentous Growth in Saccharomyces cerevisiae and Candida albicans and Is Required for C. albicans Virulence
Lisa Lapradea, Victor L. Boyartchuka, William F. Dietricha,b, and Fred Winstonaa Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
b Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
Corresponding author: Fred Winston, Harvard Medical School, 200 Longwood Ave., Boston, MA 02115., winston{at}rascal.med.harvard.edu (E-mail)
Communicating editor: A. P. MITCHELL
/spt3
filamentous growth defect. To extend our studies of Spt3's role in filamentous growth to the pathogenic yeast Candida albicans, we have identified the C. albicans SPT3 gene and have studied its role in C. albicans filamentous growth and virulence. Surprisingly, C. albicans spt3
/spt3
mutants are hyperfilamentous, the opposite phenotype observed for S. cerevisiae spt3
/spt3
mutants. Furthermore, C. albicans spt3
/spt3
mutants are avirulent in mice. These experiments demonstrate that Spt3 plays important but opposite roles in filamentous growth in S. cerevisiae and C. albicans.
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