Genetics, Vol. 160, 1749-1753, April 2002, Copyright © 2002

Invasive Filamentous Growth of Candida albicans Is Promoted by Czf1p-Dependent Relief of Efg1p-Mediated Repression

Angela D. Giusania, Marcelo Vincesa, and Carol A. Kumamotoa
a Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111

Corresponding author: Carol A. Kumamoto, Tufts University, 136 Harrison Ave., Boston, MA 02111., carol.kumamoto{at}tufts.edu (E-mail)

Communicating editor: A. P. MITCHELL

Filamentation of Candida albicans occurs in response to many environmental cues. During growth within matrix, Efg1p represses filamentation and Czf1p relieves this repression. We propose that Czf1p interacts with Efg1p, altering its function. The complex regulation of filamentation may reflect the versatility of C. albicans as a pathogen.




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