Mapping Baroreceptor Function to Genome: A Mathematical Modeling Approach

Mapping Baroreceptor Function to Genome: A Mathematical Modeling Approach

C. M. Kendziorski^a, A. W. Cowley, Jr.^b, A. S. Greene^b, H. C. Salgado^d, H. J. Jacob^b, and P. J. Tonellato^b,c
^a Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin 53706,
^b Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53233
^c Informatics Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53233
^d Department of Physiology, University of Sao Paulo, Sao Paulo 14049-900, Brazil

Corresponding author: C. M. Kendziorski, University of Wisconsin, 1300 University Ave., 6785 MSC, Madison, WI 53706., kendzior{at}biostat.wisc.edu (E-mail)

Communicating editor: G. A. CHURCHILL

To gain information about the genetic basis of a complex diseasesuch as hypertension, blood pressure averages are often obtainedand used as phenotypes in genetic mapping studies. In contrast,direct measurements of physiological regulatory mechanisms arenot often obtained, due in large part to the time and expenserequired. As a result, little information about the geneticbasis of physiological controlling mechanisms is available.Such information is important for disease diagnosis and treatment.In this article, we use a mathematical model of blood pressureto derive phenotypes related to the baroreceptor reflex, a short-termcontroller of blood pressure. The phenotypes are then used ina quantitative trait loci (QTL) mapping study to identify apotential genetic basis of this controller.

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