Genetics, Vol. 160, 805-813, February 2002, Copyright © 2002

Multiple Subunits of the Caenorhabditis elegans Anaphase-Promoting Complex Are Required for Chromosome Segregation During Meiosis I

Edward S. Davisa, Lucia Willeb, Barry A. Chestnuta, Penny L. Sadlera, Diane C. Shakesb, and Andy Goldena
a Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0840
b Department of Biology, College of William and Mary, Williamsburg, Virginia 23187

Corresponding author: Andy Golden, NIDDK/NIH, Bldg. 8, Rm. 323, 8 Center Dr. MSC 0840, Bethesda, MD 20892-0840., andyg{at}intra.niddk.nih.gov (E-mail)

Communicating editor: B. J. MEYER

Two genes, originally identified in genetic screens for Caenorhabditis elegans mutants that arrest in metaphase of meiosis I, prove to encode subunits of the anaphase-promoting complex or cyclosome (APC/C). RNA interference studies reveal that these and other APC/C subunits are essential for the segregation of chromosomal homologs during meiosis I. Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion.




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