Caenorhabditis elegans unc-37/groucho Interacts Genetically With Components of the Transcriptional Mediator Complex

Caenorhabditis elegans unc-37/groucho Interacts Genetically With Components of the Transcriptional Mediator Complex

Hong Zhang^a and Scott W. Emmons^a
^a Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461

Corresponding author: Scott W. Emmons, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461., emmons{at}aecom.yu.edu (E-mail)

Communicating editor: P. ANDERSON

Groucho functions as a general corepressor by modulating chromatinstructure and has a widespread role in many developmental processes.Here we show that Groucho may also interact with the basal transcriptionalmachinery. Mutations in Caenorhabditis elegans groucho interactwith mutations in components of the transcriptional Mediatorcomplex, resulting in synthetic lethality and loss of male sensoryneurons.

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