Genetics, Vol. 160, 765-777, February 2002, Copyright © 2002

Detecting a Local Signature of Genetic Hitchhiking Along a Recombining Chromosome

Yuseob Kima,b and Wolfgang Stephana
a Department of Evolutionary Biology, University of Munich, 80333 Munich, Germany
b Department of Biology, University of Rochester, Rochester, New York 14627

Corresponding author: Wolfgang Stephan, University of Munich, Luisentstr. 14, 80333 Munich, Germany., stephan{at}zi.biologie.uni-muenchen.de (E-mail)

Communicating editor: Y.-X. FU

The theory of genetic hitchhiking predicts that the level of genetic variation is greatly reduced at the site of strong directional selection and increases as the recombinational distance from the site of selection increases. This characteristic pattern can be used to detect recent directional selection on the basis of DNA polymorphism data. However, the large variance of nucleotide diversity in samples of moderate size imposes difficulties in detecting such patterns. We investigated the patterns of genetic variation along a recombining chromosome by constructing ancestral recombination graphs that are modified to incorporate the effect of genetic hitchhiking. A statistical method is proposed to test the significance of a local reduction of variation and a skew of the frequency spectrum caused by a hitchhiking event. This method also allows us to estimate the strength and the location of directional selection from DNA sequence data.




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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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