help button home button Genetics J Clin Inv
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Galindo, K.
Right arrow Articles by Smith, D. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Galindo, K.
Right arrow Articles by Smith, D. P.
Genetics, Vol. 159, 1059-1072, November 2001, Copyright © 2001

A Large Family of Divergent Drosophila Odorant-Binding Proteins Expressed in Gustatory and Olfactory Sensilla

Kathleen Galindoa and Dean P. Smitha
a Department of Pharmacology and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111

Corresponding author: Dean P. Smith, Department of Pharmacology and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9111., Dean.Smith{at}UTSouthwestern.edu (E-mail)

Communicating editor: T. F. C. MACKAY

We identified a large family of putative odorant-binding protein (OBP) genes in the genome of Drosophila melanogaster. Some of these genes are present in large clusters in the genome. Most members are expressed in various taste organs, including gustatory sensilla in the labellum, the pharyngeal labral sense organ, dorsal and ventral cibarial organs, as well as taste bristles located on the wings and tarsi. Some of the gustatory OBPs are expressed exclusively in taste organs, but most are expressed in both olfactory and gustatory sensilla. Multiple binding proteins can be coexpressed in the same gustatory sensillum. Cells in the tarsi that express OBPs are required for normal chemosensation mediated through the leg, as ablation of these cells dramatically reduces the sensitivity of the proboscis extension reflex to sucrose. Finally, we show that OBP genes expressed in the pharyngeal taste sensilla are still expressed in the poxneuro genetic background while OBPs expressed in the labellum are not. These findings support a broad role for members of the OBP family in gustation and olfaction and suggest that poxneuro is required for cell fate determination of labellar but not pharyngeal taste organs.




This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
A. Kopp, O. Barmina, A. M. Hamilton, L. Higgins, L. M. McIntyre, and C. D. Jones
Evolution of Gene Expression in the Drosophila Olfactory System
Mol. Biol. Evol., June 1, 2008; 25(6): 1081 - 1092.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
T. Matsuo
Rapid Evolution of Two Odorant-Binding Protein Genes, Obp57d and Obp57e, in the Drosophila melanogaster Species Group
Genetics, February 1, 2008; 178(2): 1061 - 1072.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
P. Wang, R. F. Lyman, S. A. Shabalina, T. F. C. Mackay, and R. R. H. Anholt
Association of Polymorphisms in Odorant-Binding Protein Genes With Variation in Olfactory Response to Benzaldehyde in Drosophila
Genetics, November 1, 2007; 177(3): 1655 - 1665.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
S. M. Rollmann, A. Yamamoto, T. Goossens, L. Zwarts, Z. Callaerts-Vegh, P. Callaerts, K. Norga, T. F. C. Mackay, and R. R. H. Anholt
The Early Developmental Gene Semaphorin 5c Contributes to Olfactory Behavior in Adult Drosophila
Genetics, June 1, 2007; 176(2): 947 - 956.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. Sanchez-Gracia and J. Rozas
Unusual Pattern of Nucleotide Sequence Variation at the OS-E and OS-F Genomic Regions of Drosophila simulans
Genetics, April 1, 2007; 175(4): 1923 - 1935.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
S. Foret and R. Maleszka
Function and evolution of a gene family encoding odorant binding-like proteins in a social insect, the honey bee (Apis mellifera)
Genome Res., November 1, 2006; 16(11): 1404 - 1413.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
Z. Yang, H. J. Edenberg, and R. L. Davis
Isolation of mRNA from specific tissues of Drosophila by mRNA tagging
Nucleic Acids Res., October 4, 2005; 33(17): e148 - e148.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
M. J. B. Krieger and K. G. Ross
Molecular Evolutionary Analyses of the Odorant-Binding Protein Gene Gp-9 in Fire Ants and Other Solenopsis Species
Mol. Biol. Evol., October 1, 2005; 22(10): 2090 - 2103.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. Takahashi and T. Takano-Shimizu
A High-Frequency Null Mutant of an Odorant-Binding Protein Gene, Obp57e, in Drosophila melanogaster
Genetics, June 1, 2005; 170(2): 709 - 718.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
K. G. Ross, M. J. B. Krieger, and D. D. Shoemaker
Alternative Genetic Foundations for a Key Social Polymorphism in Fire Ants
Genetics, December 1, 2003; 165(4): 1853 - 1867.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. Sanchez-Gracia, M. Aguade, and J. Rozas
Patterns of Nucleotide Polymorphism and Divergence in the Odorant-Binding Protein Genes OS-E and OS-F: Analysis in the Melanogaster Species Subgroup of Drosophila
Genetics, November 1, 2003; 165(3): 1279 - 1288.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
L. A. Graham, D. Brewer, G. Lajoie, and P. L. Davies
Characterization of a Subfamily of Beetle Odorant-binding Proteins Found in Hemolymph
Mol. Cell. Proteomics, August 1, 2003; 2(8): 541 - 549.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
D. S. Hekmat-Scafe, C. R. Scafe, A. J. McKinney, and M. A. Tanouye
Genome-Wide Analysis of the Odorant-Binding Protein Gene Family in Drosophila melanogaster
Genome Res., September 1, 2002; 12(9): 1357 - 1369.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
M. Koganezawa and I. Shimada
Novel Odorant-binding Proteins Expressed in the Taste Tissue of the Fly
Chem Senses, May 1, 2002; 27(4): 319 - 332.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
R. G. Vogt, M. E. Rogers, M.-d. Franco, and M. Sun
A comparative study of odorant binding protein genes: differential expression of the PBP1-GOBP2 gene cluster in Manduca sexta (Lepidoptera) and the organization of OBP genes in Drosophila melanogaster (Diptera)
J. Exp. Biol., March 15, 2002; 205(6): 719 - 744.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the Genetics Society of America.