Recombination in Human Mitochondrial DNA?

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Recombination in Human Mitochondrial DNA?

Carsten Wiuf^a
^a Department of Statistics, University of Oxford, Oxford OX1 3TG, United Kingdom

Corresponding author: Carsten Wiuf, 1 S. Parks Rd., Oxford OX1 3TG, England., wiuf{at}stats.ox.ac.uk (E-mail)

Communicating editor: J. HEIN

The possibility of recombination in human mitochondrial DNA(mtDNA) has been hotly debated over the last few years. In thisstudy, a general model of recombination in circular moleculesis developed and applied to a recently published African sample(n = 21) of complete mtDNA sequences. It is shown that the powerof correlation measures to detect recombination in circularmolecules can be vanishingly small and that the data are consistentwith the given model and no recombination only if the overallheterogeneity in mutation rate is <0.09.