Genetics, Vol. 158, 1217-1226, July 2001, Copyright © 2001

Quantitative Trait Locus Mapping in Laboratory Mice Derived From a Replicated Selection Experiment for Open-Field Activity

Maria Grazia Turria, Norman D. Hendersonb, John C. DeFriesc, and Jonathan Flinta
a Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, United Kingdom,
b Oberlin College, Oberlin, Ohio 44074-1086
c Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309

Corresponding author: Jonathan Flint, Wellcome Trust Centre for Human Genetics, Roosevelt Dr., Headington, Oxford, OX3 7BN, United Kingdom., jf{at}molbiol.ox.ac.uk (E-mail)

Communicating editor: G. A. CHURCHILL

Bidirectional selection in rodents has been used to derive animal models of human behavior. An important question is whether selection for behavior operates on a limited number of QTL or whether the number and individual contribution of QTL varies between selection experiments. To address this question, we mapped QTL in two large F2 intercrosses (N = 815 and 821) from the four lines derived from a replicated selection experiment for open-field activity, an animal model for susceptibility to anxiety. Our analyses indicate that selection operated on the same relatively small number of loci in both crosses. Haplotype information and the direction of effect of each QTL allele were used to confirm that the QTL mapped in the two crosses lie in the same chromosomal regions, although we were unable to determine whether QTL in the two crosses represent the same genes. We conclude that the genetic architecture of the selected strains is similar and relatively simple.




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