- THIS ARTICLE
- Full Text
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Trapp, S. C.
- Articles by Croteau, R. B.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Trapp, S. C.
- Articles by Croteau, R. B.
Genomic Organization of Plant Terpene Synthases and Molecular Evolutionary Implications
Susan C. Trappa and Rodney B. Croteauaa Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340
Corresponding author: Rodney B. Croteau, Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6340., croteau{at}mail.wsu.edu (E-mail)
Communicating editor: V. L. CHANDLER
-bisabolene (C15),
-selinene (C15), and abietadiene synthase (C20) from Abies grandis and taxadiene synthase (C20) from Taxus brevifolia], all of which are involved in natural products biosynthesis. Genome organization (intron number, size, placement and phase, and exon size) of these gymnosperm terpene synthases was compared to eight previously characterized angiosperm terpene synthase genes and to six putative terpene synthase genomic sequences from Arabidopsis thaliana. Three distinct classes of terpene synthase genes were discerned, from which assumed patterns of sequential intron loss and the loss of an unusual internal sequence element suggest that the ancestral terpenoid synthase gene resembled a contemporary conifer diterpene synthase gene in containing at least 12 introns and 13 exons of conserved size. A model presented for the evolutionary history of plant terpene synthases suggests that this superfamily of genes responsible for natural products biosynthesis derived from terpene synthase genes involved in primary metabolism by duplication and divergence in structural and functional specialization. This novel molecular evolutionary approach focused on genes of secondary metabolism may have broad implications for the origins of natural products and for plant phylogenetics in general.
This article has been cited by other articles:
![]() |
M.-A. Hartmann The way the dioecious plant Actinidia deliciosa attracts bees: critical role of volatile terpenes released from kiwifruit flowers of both genotypes J. Exp. Bot., July 8, 2009; (2009) erp224v1. [Full Text] [PDF] |
||||
![]() |
G. Wang and R. A. Dixon Heterodimeric geranyl(geranyl)diphosphate synthase from hop (Humulus lupulus) and the evolution of monoterpene biosynthesis PNAS, June 16, 2009; 106(24): 9914 - 9919. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-B. Kim, S.-M. Kim, M.-K. Kang, T. Kuzuyama, J. K. Lee, S.-C. Park, S.-c. Shin, and S.-U. Kim Regulation of resin acid synthesis in Pinus densiflora by differential transcription of genes encoding multiple 1-deoxy-D-xylulose 5-phosphate synthase and 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase genes Tree Physiol, May 1, 2009; 29(5): 737 - 749. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Lee and J. Chappell Biochemical and Genomic Characterization of Terpene Synthases in Magnolia grandiflora Plant Physiology, July 1, 2008; 147(3): 1017 - 1033. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Komatsu, M. Tsuda, S. Omura, H. Oikawa, and H. Ikeda Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol PNAS, May 27, 2008; 105(21): 7422 - 7427. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Herde, K. Gartner, T. G. Kollner, B. Fode, W. Boland, J. Gershenzon, C. Gatz, and D. Tholl Identification and Regulation of TPS04/GES, an Arabidopsis Geranyllinalool Synthase Catalyzing the First Step in the Formation of the Insect-Induced Volatile C16-Homoterpene TMTT PLANT CELL, April 1, 2008; 20(4): 1152 - 1168. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Lin, B. Shen, Z. Xu, T. G. Kollner, J. Degenhardt, and H. K. Dooner Characterization of the Monoterpene Synthase Gene tps26, the Ortholog of a Gene Induced by Insect Herbivory in Maize Plant Physiology, March 1, 2008; 146(3): 940 - 951. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. G. Kollner, M. Held, C. Lenk, I. Hiltpold, T. C.J. Turlings, J. Gershenzon, and J. Degenhardt A Maize (E)-{beta}-Caryophyllene Synthase Implicated in Indirect Defense Responses against Herbivores Is Not Expressed in Most American Maize Varieties PLANT CELL, February 1, 2008; 20(2): 482 - 494. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. I. Keeling, S. Weisshaar, R. P. C. Lin, and J. Bohlmann Functional plasticity of paralogous diterpene synthases involved in conifer defense PNAS, January 22, 2008; 105(3): 1085 - 1090. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. D. Sharkey, A. E. Wiberley, and A. R. Donohue Isoprene Emission from Plants: Why and How Ann. Bot., January 1, 2008; 101(1): 5 - 18. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Perez-Sanchez, F. Infante, C. Galvez, and J.L. Ubera Fungitoxic Activity Against Phytopathogenic Fungi and the Chemical Composition of Thymus zygis Essential Oils Food Science and Technology International, October 1, 2007; 13(5): 341 - 347. [Abstract] [PDF] |
||||
![]() |
S. C. Kampranis, D. Ioannidis, A. Purvis, W. Mahrez, E. Ninga, N. A. Katerelos, S. Anssour, J. M. Dunwell, J. Degenhardt, A. M. Makris, et al. Rational Conversion of Substrate and Product Specificity in a Salvia Monoterpene Synthase: Structural Insights into the Evolution of Terpene Synthase Function PLANT CELL, June 1, 2007; 19(6): 1994 - 2005. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. C. Hyatt, B. Youn, Y. Zhao, B. Santhamma, R. M. Coates, R. B. Croteau, and C. Kang Structure of limonene synthase, a simple model for terpenoid cyclase catalysis PNAS, March 27, 2007; 104(13): 5360 - 5365. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. T. Greenhagen, P. E. O'Maille, J. P. Noel, and J. Chappell Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases PNAS, June 27, 2006; 103(26): 9826 - 9831. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Wu, M. A. Schoenbeck, B. T. Greenhagen, S. Takahashi, S. Lee, R. M. Coates, and J. Chappell Surrogate Splicing for Functional Analysis of Sesquiterpene Synthase Genes Plant Physiology, July 1, 2005; 138(3): 1322 - 1333. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. D. Sharkey, S. Yeh, A. E. Wiberley, T. G. Falbel, D. Gong, and D. E. Fernandez Evolution of the Isoprene Biosynthetic Pathway in Kudzu Plant Physiology, February 1, 2005; 137(2): 700 - 712. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Aharoni, A. P. Giri, F. W.A. Verstappen, C. M. Bertea, R. Sevenier, Z. Sun, M. A. Jongsma, W. Schwab, and H. J. Bouwmeester Gain and Loss of Fruit Flavor Compounds Produced by Wild and Cultivated Strawberry Species PLANT CELL, November 1, 2004; 16(11): 3110 - 3131. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. M. Martin, J. Faldt, and J. Bohlmann Functional Characterization of Nine Norway Spruce TPS Genes and Evolution of Gymnosperm Terpene Synthases of the TPS-d Subfamily Plant Physiology, August 1, 2004; 135(4): 1908 - 1927. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Qi, S. Bakht, M. Leggett, C. Maxwell, R. Melton, and A. Osbourn A gene cluster for secondary metabolism in oat: Implications for the evolution of metabolic diversity in plants PNAS, May 25, 2004; 101(21): 8233 - 8238. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. G. Kollner, C. Schnee, J. Gershenzon, and J. Degenhardt The Variability of Sesquiterpenes Emitted from Two Zea mays Cultivars Is Controlled by Allelic Variation of Two Terpene Synthase Genes Encoding Stereoselective Multiple Product Enzymes PLANT CELL, May 1, 2004; 16(5): 1115 - 1131. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Dudareva, D. Martin, C. M. Kish, N. Kolosova, N. Gorenstein, J. Faldt, B. Miller, and J. Bohlmann (E)-{beta}-Ocimene and Myrcene Synthase Genes of Floral Scent Biosynthesis in Snapdragon: Function and Expression of Three Terpene Synthase Genes of a New Terpene Synthase Subfamily PLANT CELL, May 1, 2003; 15(5): 1227 - 1241. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. E. Cane and R. M. Watt Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis PNAS, February 18, 2003; 100(4): 1547 - 1551. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Schnee, T. G. Kollner, J. Gershenzon, and J. Degenhardt The Maize Gene terpene synthase 1 Encodes a Sesquiterpene Synthase Catalyzing the Formation of (E)-beta -Farnesene, (E)-Nerolidol, and (E,E)-Farnesol after Herbivore Damage Plant Physiology, December 1, 2002; 130(4): 2049 - 2060. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. A. Whittington, M. L. Wise, M. Urbansky, R. M. Coates, R. B. Croteau, and D. W. Christianson Bornyl diphosphate synthase: Structure and strategy for carbocation manipulation by a terpenoid cyclase PNAS, November 26, 2002; 99(24): 15375 - 15380. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. J. Bouwmeester, J. Kodde, F. W.A. Verstappen, I. G. Altug, J.-W. de Kraker, and T. E. Wallaart Isolation and Characterization of Two Germacrene A Synthase cDNA Clones from Chicory Plant Physiology, May 1, 2002; 129(1): 134 - 144. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Burke and R. Croteau Interaction with the Small Subunit of Geranyl Diphosphate Synthase Modifies the Chain Length Specificity of Geranylgeranyl Diphosphate Synthase to Produce Geranyl Diphosphate J. Biol. Chem., January 25, 2002; 277(5): 3141 - 3149. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. J. Peters and R. B. Croteau Abietadiene synthase catalysis: Mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement PNAS, January 22, 2002; 99(2): 580 - 584. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Vainstein, E. Lewinsohn, E. Pichersky, and D. Weiss Floral Fragrance. New Inroads into an Old Commodity Plant Physiology, December 1, 2001; 127(4): 1383 - 1389. [Full Text] [PDF] |
||||
![]() |
B. Greenhagen and J. Chappell Molecular scaffolds for chemical wizardry: Learning nature's rules for terpene cyclases PNAS, November 20, 2001; 98(24): 13479 - 13481. [Full Text] [PDF] |
||||







