Measuring Gametic Disequilibrium From Multilocus Data

Corresponding author: David J. Balding, Department of Applied Statistics, University of Reading, P.O. Box 240, Earley Gate, Reading RG6 6FN, United Kingdom., d.j.balding{at}rdg.ac.uk (E-mail)

Communicating editor: G. A. CHURCHILL

We describe a Bayesian approach to analyzing multilocus genotype or haplotype data to assess departures from gametic (linkage) equilibrium. Our approach employs a Markov chain Monte Carlo (MCMC) algorithm to approximate the posterior probability distributions of disequilibrium parameters. The distributions are computed exactly in some simple settings. Among other advantages, posterior distributions can be presented visually, which allows the uncertainties in parameter estimates to be readily assessed. In addition, background knowledge can be incorporated, where available, to improve the precision of inferences. The method is illustrated by application to previously published datasets; implications for multilocus forensic match probabilities and for simple association-based gene mapping are also discussed.

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