Genetics, Vol. 155, 1405-1413, July 2000, Copyright © 2000

Hitchhiking Under Positive Darwinian Selection

Justin C. Faya and Chung-I Wua,b
a Committee on Genetics, University of Chicago, Chicago, Illinois 60637
b Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637

Corresponding author: Chung-I Wu, Department of Ecology and Evolution, University of Chicago, 1101 E. 57th St., Chicago, IL 60637., ciwu{at}uchicago.edu (E-mail)

Communicating editor: W. STEPHAN

Positive selection can be inferred from its effect on linked neutral variation. In the restrictive case when there is no recombination, all linked variation is removed. If recombination is present but rare, both deterministic and stochastic models of positive selection show that linked variation hitchhikes to either low or high frequencies. While the frequency distribution of variation can be influenced by a number of evolutionary processes, an excess of derived variants at high frequency is a unique pattern produced by hitchhiking (derived refers to the nonancestral state as determined from an outgroup). We adopt a statistic, H, to measure an excess of high compared to intermediate frequency variants. Only a few high-frequency variants are needed to detect hitchhiking since not many are expected under neutrality. This is of particular utility in regions of low recombination where there is not much variation and in regions of normal or high recombination, where the hitchhiking effect can be limited to a small (<1 kb) region. Application of the H test to published surveys of Drosophila variation reveals an excess of high frequency variants that are likely to have been influenced by positive selection.




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J. E. Pool and C. F. Aquadro
History and Structure of Sub-Saharan Populations of Drosophila melanogaster
Genetics, October 1, 2006; 174(2): 915 - 929.
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 Mol Biol EvolHome page
S. Glinka, D. De Lorenzo, and W. Stephan
Evidence of Gene Conversion Associated with a Selective Sweep in Drosophila melanogaster
Mol. Biol. Evol., October 1, 2006; 23(10): 1869 - 1878.
[Abstract] [Full Text] [PDF]

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 GeneticsHome page
T. M. Panhuis and W. J. Swanson
Molecular Evolution and Population Genetic Analysis of Candidate Female Reproductive Genes in Drosophila
Genetics, August 1, 2006; 173(4): 2039 - 2047.
[Abstract] [Full Text] [PDF]

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 Am. J. Bot.Home page
I. M. Ehrenreich and M. D. Purugganan
The molecular genetic basis of plant adaptation
Am. J. Botany, July 1, 2006; 93(7): 953 - 962.
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 Hum Mol GenetHome page
J. M. Akey, W. J. Swanson, J. Madeoy, M. Eberle, and M. D. Shriver
TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations
Hum. Mol. Genet., July 1, 2006; 15(13): 2106 - 2113.
[Abstract] [Full Text] [PDF]

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 GeneticsHome page
H. Innan
Modified Hudson-Kreitman-Aguade Test and Two-Dimensional Evaluation of Neutrality Tests
Genetics, July 1, 2006; 173(3): 1725 - 1733.
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 ScienceHome page
P. C. Sabeti, S. F. Schaffner, B. Fry, J. Lohmueller, P. Varilly, O. Shamovsky, A. Palma, T. S. Mikkelsen, D. Altshuler, and E. S. Lander
Positive natural selection in the human lineage.
Science, June 16, 2006; 312(5780): 1614 - 1620.
[Abstract] [Full Text] [PDF]

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 Genome ResHome page
K. M. Teshima, G. Coop, and M. Przeworski
How reliable are empirical genomic scans for selective sweeps?
Genome Res., June 1, 2006; 16(6): 702 - 712.
[Abstract] [Full Text] [PDF]

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 GeneticsHome page
M. T. Hamblin, A. M. Casa, H. Sun, S. C. Murray, A. H. Paterson, C. F. Aquadro, and S. Kresovich
Challenges of Detecting Directional Selection After a Bottleneck: Lessons From Sorghum bicolor
Genetics, June 1, 2006; 173(2): 953 - 964.
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 Proc. Natl. Acad. Sci. USAHome page
J. M. Comeron
Weak selection and recent mutational changes influence polymorphic synonymous mutations in humans
PNAS, May 2, 2006; 103(18): 6940 - 6945.
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 Mol Biol EvolHome page
A. J. Greenberg and C.-I Wu
Molecular Genetics of Natural Populations
Mol. Biol. Evol., May 1, 2006; 23(5): 883 - 886.
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 Mol Biol EvolHome page
S. Ihle, I. Ravaoarimanana, M. Thomas, and D. Tautz
An Analysis of Signatures of Selective Sweeps in Natural Populations of the House Mouse
Mol. Biol. Evol., April 1, 2006; 23(4): 790 - 797.
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 GeneticsHome page
K. Thornton and P. Andolfatto
Approximate Bayesian Inference Reveals Evidence for a Recent, Severe Bottleneck in a Netherlands Population of Drosophila melanogaster
Genetics, March 1, 2006; 172(3): 1607 - 1619.
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