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Genetics, Vol. 155, 989-992, June 2000, Copyright © 2000

A Glucose Transporter Chimera Confers a Dominant Negative Glucose Starvation Phenotype in Saccharomyces cerevisiae

Peter W. Sherwooda, Iskra Katica, Pascual Sanza, and Marian Carlsona
a Department of Genetics and Development, Columbia University, New York, New York 10032

Corresponding author: Marian Carlson, Columbia University, 701 W. 168th St., HHSC 922, New York, NY 10032., mbc1{at}columbia.edu (E-mail)

Communicating editor: M. JOHNSTON

A family of glucose transporters mediates glucose uptake in Saccharomyces cerevisiae. We show that the dominant mutation GSF4-1, which impairs glucose repression of SUC2, results in a nonfunctional chimera of the transporters Hxt1p and Hxt4p. Hxt1/4p inhibits the function of wild-type glucose transporters. Similar mutations may facilitate analysis of the major facilitator superfamily.




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