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Genetics, Vol. 155, 309-322, May 2000, Copyright © 2000

Comparative Genetics of Nucleotide Binding Site-Leucine Rich Repeat Resistance Gene Homologues in the Genomes of Two Dicotyledons: Tomato and Arabidopsis

Qilin Pana, Yong-Sheng Liub, Ofra Budai-Hadriana, Marianne Selaa, Lea Carmel-Gorenc, Dani Zamirc, and Robert Fluhra
a Department of Plant Science, Weizmann Institute of Science, Rehovot 76100, Israel,
b Institute of Botany, Chinese Academy of Sciences, Beijing 100093, People's Republic of China
c Department of Field and Vegetable Crops, Faculty of Agriculture, Environment and Food Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel

Corresponding author: Robert Fluhr, Weizmann Institute of Science, P.O. Box 26, Rehovot, Israel 76100., lpfluhr{at}weizmann.weizmann.ac.il (E-mail)

Communicating editor: C. S. GASSER

The presence of a single resistance (R) gene allele can determine plant disease resistance. The protein products of such genes may act as receptors that specifically interact with pathogen-derived factors. Most functionally defined R-genes are of the nucleotide binding site-leucine rich repeat (NBS-LRR) supergene family and are present as large multigene families. The specificity of R-gene interactions together with the robustness of plant-pathogen interactions raises the question of their gene number and diversity in the genome. Genomic sequences from tomato showing significant homology to genes conferring race-specific resistance to pathogens were identified by systematically "scanning" the genome using a variety of primer pairs based on ubiquitous NBS motifs. Over 70 sequences were isolated and 10% are putative pseudogenes. Mapping of the amplified sequences on the tomato genetic map revealed their organization as mixed clusters of R-gene homologues that showed in many cases linkage to genetically characterized tomato resistance loci. Interspecific examination within Lycopersicon showed the existence of a null allele. Consideration of the tomato and potato comparative genetic maps unveiled conserved syntenic positions of R-gene homologues. Phylogenetic clustering of R-gene homologues within tomato and other Solanaceae family members was observed but not with R-gene homologues from Arabidopsis thaliana. Our data indicate remarkably rapid evolution of R-gene homologues during diversification of plant families.




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