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Genetics, Vol. 154, 747-758, February 2000, Copyright © 2000

The Clock Gene period of the Housefly, Musca domestica, Rescues Behavioral Rhythmicity in Drosophila melanogaster: Evidence for Intermolecular Coevolution?

Alberto Piccina, Martin Couchmana, Jonathan D. Claytona, David Chalmersa, Rodolfo Costab, and Charalambos P. Kyriacoua
a Department of Genetics, University of Leicester, Leicester LE1 7RH, United Kingdom
b Dipartimento di Biologia, Università di Padova, 35131 Padova, Italy

Corresponding author: Charalambos P. Kyriacou, Department of Genetics, University of Leicester, University Rd., Leicester LE1 7RH, United Kingdom., cpk{at}leicester.ac.uk (E-mail)

Communicating editor: J. J. LOROS

In Drosophila, the clock gene period (per), is an integral component of the circadian clock and acts via a negative autoregulatory feedback loop. Comparative analyses of per genes in insects and mammals have revealed that they may function in similar ways. However in the giant silkmoth, Antheraea pernyi, per expression and that of the partner gene, tim, is not consistent with the negative feedback role. As an initial step in developing an alternative dipteran model to Drosophila, we have identified the per orthologue in the housefly, Musca domestica. The Musca per sequence highlights a pattern of conservation and divergence similar to other insect per genes. The PAS dimerization domain shows an unexpected phylogenetic relationship in comparison with the corresponding region of other Drosophila species, and this appears to correlate with a functional assay of the Musca per transgene in Drosophila melanogaster per-mutant hosts. A simple hypothesis based on the coevolution of the PERIOD and TIMELESS proteins with respect to the PER PAS domain can explain the behavioral data gathered from transformants.




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