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Genetics, Vol. 153, 773-786, October 1999, Copyright © 1999

An Analysis of Polygenes Affecting Wing Shape on Chromosome 3 in Drosophila melanogaster

Kenneth Webera, Robert Eismana, Lisa Moreya, April Pattya, Joshua Sparksa, Michele Tauseka, and Zhao-Bang Zengb
a Department of Biological Sciences, University of Southern Maine, Portland, Maine 04104-9300
b Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695-8203

Corresponding author: Kenneth Weber, Department of Biological Sciences, University of Southern Maine, Box 9300, Portland, ME 04104-9300., keweber{at}usm.maine.edu (E-mail)

Communicating editor: A. G. CLARK

Loci on the third chromosome of Drosophila melanogaster that affect an index of wing shape were mapped, using recombinant isogenic lines, with transposable elements as markers. Many genes with small subequal effects are dispersed along the whole chromosome. Their alleles act nearly additively in heterozygotes. They have small correlated effects on leg shape, but no detectable effects on halteres. Small negative net interactions occur over most of the chromosome. The data set of 519 recombinant isogenic lines can be explained reasonably well by two models. One model posits an indefinitely large number of loci with no interactions. The other model posits 11 loci with additive effects whose sum equals the total phenotypic range and with large positive and negative interactions that nearly cancel each other.




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