Genetics, Vol. 151, 803-820, February 1999, Copyright © 1999

A Second-Generation Genetic Linkage Map of the Domestic Dog, Canis familiaris

Mark W. Neffa, Karl W. Bromanb, Cathryn S. Mellershc, Kunal Rayd, Gregory M. Aclandd, Gustavo D. Aguirred, Janet S. Zieglee, Elaine A. Ostranderc, and Jasper Rinea
a Department of Molecular and Cell Biology, University of California, Berkeley, California 94720,
b Marshfield Medical Research Foundation, Marshfield, Wisconsin 54449,
c Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109,
d Center for Canine Genetics and Reproduction, James A. Baker Institute for Animal Health, Cornell University,
e Ithaca, New York 14853 PE Applied Biosystems, Foster City, California 94404

Corresponding author: Jasper Rine, Department of Molecular and Cell Biology, University of California, Berkeley, 401 Barker Hall #3204, Berkeley, CA 94720-3204., jrine{at}uclink4.berkeley.edu (E-mail)

Communicating editor: D. BOTSTEIN

Purebred strains, pronounced phenotypic variation, and a high incidence of heritable disease make the domestic dog uniquely suited to complement genetic analyses in humans and mice. A comprehensive genetic linkage map would afford many opportunities in dogs, ranging from the positional cloning of disease genes to the dissection of quantitative differences in size, shape, and behavior. Here we report a canine linkage map with the number of mapped loci expanded to 276 and 10-cM coverage extended to 75–90% of the genome. Most of the 38 canine autosomes are likely represented in the collection of 39 autosomal linkage groups. Eight markers were sufficiently informative to detect linkage at distances of 10–13 cM, yet remained unlinked to any other marker. Taken together, the results suggested a genome size of about 27 M. As in other species, the genetic length varied between sexes, with the female autosomal distance being ~1.4-fold greater than that of male meioses. Fifteen markers anchored well-described genes on the map, thereby serving as landmarks for comparative mapping in dogs. We discuss the utility of the current map and outline steps necessary for future map improvement.




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