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Genetics, Vol. 150, 1577-1584, December 1998, Copyright © 1998

Isochore Evolution in Mammals: A Human-Like Ancestral Structure

Nicolas Galtiera,b and Dominique Mouchirouda
a Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558, Biométrie, Génétique et Biologie des Populations, Université Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France
b Centre National de la Recherche Scientifique, Unité Propre de Recherche 9060, Génome et Populations, Université Montpellier 2, 34095 Montpellier Cedex, France

Corresponding author: Dominique Mouchiroud, Centre National de la Recherche Scientifique UMR 5558, Biométrie, Génétique et Biologie des Populations, Université Claude Bernard Lyon 1, 43, Boulevard du 11 novembre 1918, 69622 Villeurbanne Cedex, France., mouchi{at}biomserv.univ-lyon1.fr (E-mail).

Communicating editor: G. A. CHURCHILL

Codon usage in mammals is mainly determined by the spatial arrangement of genomic G + C-content, i.e., the isochore structure. Ancestral G + C-content at third codon positions of 27 nuclear protein-coding genes of eutherian mammals was estimated by maximum-likelihood analysis on the basis of a nonhomogeneous DNA substitution model, accounting for variable base compositions among present-day sequences. Data consistently supported a human-like ancestral pattern, i.e., highly variable G + C-content among genes. The mouse genomic structure—more narrow G + C-content distribution—would be a derived state. The circumstances of isochore evolution are discussed with respect to this result. A possible relationship between G + C-content homogenization in murid genomes and high mutation rate is proposed, consistent with the negative selection hypothesis for isochore maintenance in mammals.




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