Mouse Brachyury the Second (T2) Is a Gene Next to Classical T and a Candidate Gene for tct

Corresponding author: Karen Artzt, Department of Microbiology, MMB 2.124, 2500 Speedway A4800, University of Texas, Austin, TX 78712., artzt{at}uts.cc.utexas.edu (E-mail).

Communicating editor: N. A. JENKINS

The mouse Brachyury the Second (T2) gene is 15 kb away from classical Brachyury (T). A mutation in T2 disrupts notochord development, pointing to the existence of a second T/t complex gene involved in axis development. T2 encodes a novel protein that is disrupted by an insertion in T2^Bob mice. Sequence analysis of T2 from several t haplotypes shows that they all share the same changed stop codon, and, thus, T2 is a candidate gene for the t complex tail interaction factor. T1, T2, and the unlinked t-int are distinct and unrelated loci, and mutations in these genes do not complement one another genetically. Either their products interact in the same pathway during the genesis of the embryonic axis, or the T/t region itself is truly complex.

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