Mouse Brachyury the Second (T2) Is a Gene Next to Classical T and a Candidate Gene for tct

Mouse Brachyury the Second (T2) Is a Gene Next to Classical T and a Candidate Gene for tct

Gabriela Rennebeck^a, Eric Lader^a, Atsushi Fujimoto^a, Elissa P. Lei^a, and Karen Artzt^a
^a The Institute for Cellular and Molecular Biology, Department of Microbiology, The University of Texas, Austin, Texas 78712-1064

Corresponding author: Karen Artzt, Department of Microbiology, MMB 2.124, 2500 Speedway A4800, University of Texas, Austin, TX 78712., artzt{at}uts.cc.utexas.edu (E-mail).

Communicating editor: N. A. JENKINS

The mouse Brachyury the Second (T2) gene is 15 kb away fromclassical Brachyury (T). A mutation in T2 disrupts notochorddevelopment, pointing to the existence of a second T/t complexgene involved in axis development. T2 encodes a novel proteinthat is disrupted by an insertion in T2^Bob mice. Sequence analysisof T2 from several t haplotypes shows that they all share thesame changed stop codon, and, thus, T2 is a candidate gene forthe t complex tail interaction factor. T1, T2, and the unlinkedt-int are distinct and unrelated loci, and mutations in thesegenes do not complement one another genetically. Either theirproducts interact in the same pathway during the genesis ofthe embryonic axis, or the T/t region itself is truly complex.

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