Statistical Analysis of Half-Tetrads

Corresponding author: Hongyu Zhao, Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520., hongyu.zhao{at}yale.edu (E-mail).

Communicating editor: D. BOTSTEIN

Half-tetrads, where two meiotic products from a single meiosis are recovered together, arise in different forms in a variety of organisms. Closely related to ordered tetrads, half-tetrads yield information on chromatid interference, chiasma interference, and centromere positions. In this article, for different half-tetrad types and different marker configurations, we derive the relations between multilocus half-tetrad probabilities and multilocus ordered tetrad probabilities. These relations are used to obtain equality and inequality constraints among multilocus half-tetrad probabilities that are imposed by the assumption of no chromatid interference. We illustrate how to apply these results to study chiasma interference and to map centromeres using multilocus half-tetrad data.

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