Genetics, Vol. 149, 1069-1080, June 1998, Copyright © 1998

Multiple Marker Mapping of Quantitative Trait Loci in a Cross Between Outbred Wild Boar and Large White Pigs

Sara A. Knotta, Lena Marklundb, Chris S. Haleyd, Kjell Anderssonb, William Daviese, Hans Ellegrenb, Merete Fredholmf, Ingemar Hanssonc, Bjorn Hoyheime, Kerstin Lundströmc, Maria Mollerb, and Leif Anderssonb
a Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom,
b Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala 750 07, Sweden,
c Department of Food Science, Swedish University of Agricultural Sciences, Uppsala 750 07, Sweden,
d Roslin Institute (Edinburgh), Midlothian EM9 2ER, United Kingdom,
e Department of Biochemistry, Physiology and Nutrition, Norwegian College of Veterinary Medicine, Oslo 0033, Norway
f Department of Animal Production and Animal Health, Division of Animal Genetics, The Royal Veterinary and Agricultural University, 5 DK-1870 Frederiksberg, Denmark

Corresponding author: Sara A. Knott, Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Rd., Edinburgh EH9 3JT, UK, s.knott{at}ed.ac.uk (E-mail).

Communicating editor: T. F. C. MACKAY

A quantitative trait locus (QTL) analysis of growth and fatness data from a three generation pig experiment is presented. The population of 199 F2 animals was derived from a cross between wild boar and Large White pigs. Animals were typed for 240 markers spanning 23 Morgans of 18 autosomes and the X chromosome. A series of analyses are presented within a least squares framework. First, these identify chromosomes containing loci controlling trait variation and subsequently attempt to map QTLs to locations within chromosomes. This population gives evidence for a large QTL affecting back fat and another for abdominal fat segregating on chromosome 4. The best locations for these QTLs are within 4 cM of each other and, hence, this is likely to be a single QTL affecting both traits. The allele inherited from the wild boar causes an increase in fat deposition. A QTL for intestinal length was also located in the same region on chromosome 4 and could be the same QTL with pleiotropic effects. Significant effects, owing to multiple QTLs, for intestinal length were identified on chromosomes 3 and 5. A single QTL affecting growth rate to 30 kg was located on chromosome 13 such that the Large White allele increased early growth rate, another QTL on chromosome 10 affected growth rate from 30 to 70 kg and another on chromosome 4 affected growth rate to 70 kg.




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