- THIS ARTICLE
- Full Text
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Schaaper, R. M.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Schaaper, R. M.
Antimutator Mutants in Bacteriophage T4 and Escherichia coli
Roel M. Schaaperaa Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
Corresponding author: Roel M. Schaaper, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, 111 TW Alexander Dr., Box 12233, Research Triangle Park, NC 27709, schaaper{at}niehs.nih.gov (E-mail).
Antimutators are mutant strains that have reduced mutation rates compared to the corresponding wild-type strain. Their existence, along with mutator mutants that have higher mutation rates compared to the wild-type strain, are powerful evidence that mutation rates are genetically controlled. Compared to mutator mutants, antimutators have a very distinguishing property. Because they prevent normally occurring mutations, they, uniquely, are capable of providing insight into the mechanisms of spontaneous mutations. In this review, antimutator mutants are discussed in bacteriophage T4 and the bacterium Escherichia coli, with regard to their properties, possible mechanisms, and implications for the sources of spontaneous mutations in these two organisms.
This article has been cited by other articles:
 |
|
 |
|
  D. Gawel, P. T. Pham, I. J. Fijalkowska, P. Jonczyk, and R. M. Schaaper Role of Accessory DNA Polymerases in DNA Replication in Escherichia coli: Analysis of the dnaX36 Mutator Mutant J. Bacteriol., March 1, 2008; 190(5): 1730 - 1742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Gerrish, A. Colato, A. S. Perelson, and P. D. Sniegowski Complete genetic linkage can subvert natural selection PNAS, April 10, 2007; 104(15): 6266 - 6271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Pfeiffer and K. Kirkegaard A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity PNAS, June 10, 2003; 100(12): 7289 - 7294. [Abstract] [Full Text] [PDF]
|
|