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Genetics, Vol 147, 1769-1782, Copyright © 1997
INVESTIGATIONS |
The Accumulation of P-Element-Induced Recombinants in the Germline of Male Drosophila melanogaster
M. M. Tanaka, X. M. Liang, YHM. Gray and J. A. Sved
Corresponding author: Mark M. Tanaka, Department of Biological Sciences, Stanford University, CA 94305-5020. E-mail: markt@charles.stanford.edu
P-element-induced recombination in Drosophila melanogaster occurs premeiotically. Recombinants are therefore expected to accumulate in the stem cells of the germline of P-element-carrying males. We show that both the recombination frequency and the incidence of ``clustering'' increase with the age of males carrying various P-element derivatives. The combination of end-deleted elements can lead to average recombination frequencies >50% with individual instances of 100% recombination. These elements also lowered the fertility of the carriers. We investigated these features by constructing an analytical and a computer simulation model of the course of events in the germline, incorporating the recently proposed hybrid element insertion (HEI) model of P-element activity. The model is able to predict extreme recombination levels, segregation ratio biases and lowered fertility through cell death in a single analysis.
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